By Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)

to the Animal versions Volumes This quantity describes animal types of drug habit. due to expanding public drawback over the moral remedy of animals in learn, we felt it incumbent upon us to incorporate this normal preface with a view to point out why we expect additional examine utilizing animals is important. Animals may still in simple terms be used whilst appropriate choices usually are not on hand, and people can purely be experimented upon in seriously proscribed conditions. replacement approaches utilizing mobilephone or tissue tradition are insufficient in any versions requiring exams of behavioral switch or of advanced in vivo p- cesses. besides the fact that, whilst the misery, pain, or soreness to the animals outweighs the predicted profits for human welfare, the examine isn't really moral and shouldn't be performed. it truly is central that every person researcher research his/ her personal learn from a serious ethical point of view sooner than eng- ing in it, and think about the animals’ welfare in addition to the expected profits. in addition, as soon as a choice to p- ceed with study is made, it's the researcher’s accountability to make sure that the animals’ welfare is of top quandary by way of acceptable housing, feeding, and greatest aid of any uncomfortable or distressing results of the experimental conditions.

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Psychopharmacologia (Bed) 43,19-23. Meisch R. A. and Thompson T. (1971) Ethanol intake in the absence of concurrent food reinforcement. Psychophumcologia (Bed) 22,72-79. Meisch R. A. and Thompson T. (1974a) Rapid establishment of ethanol as a reinforcer for rats. ) 37,311-321. Meisch R. A. and Thompson T. (1974b) Ethanol intake as a function of concentration during food deprivation and satiation. Biochem. 2‘5896%. Mello N. K. (1973) A review of methods to induce alcohol addiction mals. 1,89-101.

E. and Meisch R. A. (1975) Ethanol-reinforced responding and intake as a function of volume per reinforcement. Pharmucol. Biochem. Behav. $437-441. , Dahl L. , and Knudsen K. D. (1973), Genetic influences on the renin-angiotensin system. Low renin activities in hypertension-prone rats. Circ. Res. a2,678-684. , Brown D. , McCleam G. , and Tabershaw I. R. (1966) Brain sensitivity to alcohol in inbred mouse strains. Science 154, 1574,1575. Kalant H. , Druley K. , Skododa T. , and Waxman H. , C. C.

It also follows that the individual differences in the propensity to self-administer ethanol shown by unselected rats are, at least in part, genetically transmitted. In this respect, the ethanol drinking shown by laboratory rats may mirror the variability in preference for alcohol seen in “unselected” populations of humans. The fact that most unselected rats do not self-administer large quantities of ethanol may reflect genetic variability, but some of this variability is likely to be the result of environmental factors.

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